ORGAN TOXICITY TESTING IN VITRO BIO-ASSAY : AN ALTERNATIVE METHODD.N. GANDHIAbstract Environmental pollutants or toxic chemicals interact with multiple systems of the human body resulting in homeostasis. Because of such interaction, isolated preparation in vitro bio-assay may be an adequate assay for the organ-toxic potential of toxicants. This review strictly emphasises on isolated organ/tissue preparations and its role in prediction of toxicity induced by various chemicals and/or environmental pollutants. Alternative methods that provide useful information for human health and environmental risk in all areas of toxicity testing. Certain methods/bio-assays provide mechanistic information that is useful for interpretation of data and improved prediction of toxicity. Some methods provide saving in time and cost, reduce the number of animals required for toxicological assessments and also help in future progress in the development of alternative toxicological test methods. These bioassays will provide for world-wide improvement in human health protection, environmental protection and animal welfare.
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