Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol.13, Issue 4, 2011; Page No.(677-683)

THE ANTIOXIDANT ACTIVITY OF FERULIC ACID ON MPTP INDUCED PARKINSONS DISEASE IN MICE

N. USHA RANI AND T. ANANTHI

Abstract

Antioxidant defences appears to be depleted during Parkinson disease due to oxidative stress. Various alternative medicines are employed to be increase the endogenous antioxidant level.The aim of the present study was to evaluate the antioxidant effect of ferrulic acid on the MPTP induced Parkinson disease in mice.The lipid peroxidation, activities of enzymes superoxide dismutase (SOD), catalase,TBARS, GSH and GPX were measured. The levels of TBARS activities and SOD,CAT, were increased but the levels of GSH and its dependent enzyme GPx activity were reduced in MPTP treated animals. The abnormalities caused by MPTP treatment is almost normalized by the treatment of Ferulic acid which may be due to its antioxidant effect.

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