INTESTINAL LESIONS IN RATS WITH EXPERIMENTAL TREATMENT OF ASPIRIN, A NON-STEROIDAL ANTIINFLAMMATORY DRUGGAGANPREET KAUR, S. S. KANWAR, R. K. SAINI AND S. N. SANYALAbstract The treatment of aspirin for 28 days in male Wistar rats has caused important qualitative and quantitative changes in histoarchitectural structure of the intestinal tissues. As compared to the control animals, the aspirin treated animals showed an increase in absorptive surface in terms of villi number, crypts number and villi height. The drug also brought about disruptive changes in lamina propria such as shrinkage along with distortion in the columnar cell lining. Vacuolarization of the goblet cells of villi, decrease in the size of the crypts, increased thickness of the lamina propria and broken tip of the villi are the other most characteristic features observed. There was also an increased polysaccharide concentration in the goblet cells of the villi but the moiety of polysaccharides revealed a decrease in the crypt of the aspirin treated animals. The results suggest an increase in intestinal absorption of the nutrients as observed and has a temporal relationship with the increase in the functionally active cells and thereby increased absorptive surface area in aspirin treatments.
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