IMMUNOMODULATORY POTENTIAL OF ADHATODA VASICASANTH RANI THAAKURAbstract Adhatoda vasica (AV) nees of the Actin thaceae family is a well know plant drug in Ayurvedic and Unani medicine. Several tribal populations in chittoor district of Andhra Pradesh use leaves of the plant in cold, cough and asthama. In the present study an attempt was made to explore the immunomodulatory potential of AV in male swiss albino mice. Effect of alcoholic extract of AV leaf (500mg/kg, p.o) on haematological profile, splenic lymphocytes and peritoneal macrophages was studied 5, 10, 15 and 20 days after treatment. Its effect on macrophage phagocytic index, E.coli induced abdominal peritonitis and SRBC induced delayed type hypersensitivity was also evaluated. AV showed significant increase in total WBC, blood lymphocytes, splenic lymphocytes and peritoneal macrophages. It also showed significant protection against E.coli induced abdominal peritonitis. AV leaf extract may have significant imrnunoptentiating and immunoprophylactic activity.
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