EFFECT OF METHANOL EXTRACT OF ACHYRANTHES ASPERA L. ON AFLOTOXICOSIS RATSP. VANITHA PAPPAl, P. PADMALATHA, A.J.A. RANJIT SINGH', M.A. HANIFFA4 AND M. RAJASEKARA PANDIAN
Methanolic extract of root parts of Achyranthes aspera L. (Amaranthaceae) as tested for its effect on aflotoxicosis rats at five dose levels. Aflotoxin intoxication in rats significantly (p <0.001) elevated the levels of SGPT, SGOT, ALKP, and total bilirubin, which indicated acute hepatocellular, damage and biliary obstruction. Methanol extract showed dose dependent decrease in the levels of SGPT, SCOT, ALKP and total bilirubin. Minimum effective dose of extract was found to be 100 mg/kg body weight. Results obtained from histopathological studies also supported hepatoprotective activity against aflotoxin induced hepatotoxicity. Thus the Study demonstrates that A. aspera possess anti-hepato toxic effect against aflotoxin.
Enter your contact information below to receive full paper.