Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 9, Issue 2, 2007; Page No.(297-301)

EFFECT OF METHANOL EXTRACT OF ACHYRANTHES ASPERA L. ON AFLOTOXICOSIS RATS

P. VANITHA PAPPAl, P. PADMALATHA, A.J.A. RANJIT SINGH', M.A. HANIFFA4 AND M. RAJASEKARA PANDIAN

Abstract

Methanolic extract of root parts of Achyranthes aspera L. (Amaranthaceae) as tested for its effect on aflotoxicosis rats at five dose levels. Aflotoxin intoxication in rats significantly (p <0.001) elevated the levels of SGPT, SGOT, ALKP, and total bilirubin, which indicated acute hepatocellular, damage and biliary obstruction. Methanol extract showed dose dependent decrease in the levels of SGPT, SCOT, ALKP and total bilirubin. Minimum effective dose of extract was found to be 100 mg/kg body weight. Results obtained from histopathological studies also supported hepatoprotective activity against aflotoxin induced hepatotoxicity. Thus the Study demonstrates that A. aspera possess anti-hepato toxic effect against aflotoxin.

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