Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 9, Issue 2, 2007; Page No.(281-286)

ANALYSIS ON RENAL FAILURE BLOOD SERA - A ANALYSIS ON RENAL FAILURE BLOOD SERA - A SPECTROSCOPIC APPROACH

S. GUNASEKARAN, T.S. RENUGA DEVI, M. SREENIVASAKUMAR, K. SANTHOSAM

Abstract

Kidney is a vital organ that performs many functions to keep the blood clean and chemically balanced. Healthy kidneys clean the blood by removing excess fluid, minerals and wastes. When the kidneys fail, harmful wastes build up in the body, and damage the body. A build up of these waste products in blood indicates a loss of kidney function. Dialysis is a medical process through which a person's blood is cleansed of the toxins the kidney normally would flush out. The present study was conducted to evaluate the spectral difference between healthy and renal failure blood sera and also to find the significance of dialysis in chronic renal failure patients using FTIR spectroscopic technique. To find the spectral difference between healthy and chronic renal failure blood sera ,Ten chronic renal failure patients were enrolled in this study and to analyze the significance of hemodialysis in chronic renal failure patients two dialysis patients waiting on a kidney transplant were enrolled. FT1R Spectra of blood sera were recorded over the region 4000-400 cm-1 on a Perkin Elmer spectrum one FTIR Spectrometer. The internal standard ratio among the absorption peaks were calculated and it is found to be an indicator to differentiate the diseased subjects from the healthy one. The significance of hemodialysis was also analyzed by comparing the internal standard ratios of pre and post dialysed blood sera. It is Statistically observed from the study that the internal standard ratios of specific modes of vibration of urea and creatinine is found to be more significant between healthy and renal failure subjects.

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