ANTIMICROBIAL ACTIVITY OF POLYKETIDES OF MONASCLIS PLIRPLIRELISPUSHPA S MURTHY, V. VANAJAKSHI AND G. VIJAYALAKSHMI
Ascomycetous fungus, MOULTSC115 purptireus recently has gained importance as a dietary supplement due to its anticholostemic property. En addition, Monascus has been widely used in the Oriental countries for many centuries as a natural food colorant\ and in medicine. Polyketide pigments are produced by Monascus sp. After 12 days of incubation, the total red pigment was extracted from the mouldy red rice by the solvent extraction method. The antimicrobial effect of total crude pigment was studied against pathogenic and food spoilage bacteria like Bacillus cereus, Escherichia coli, Staphylococcus aureus, Streptococcus sp., Yersinia enterocolitica and Listeria monocytogenes. Comparative studies with standard antibiotics were carried out to observe the effectiveness of the pigment. Also, antifungal activity of the pigment extract were studied against Aspergillus flavus and Fusarium sp. Antimicrobial effect was determined by standard disc plate agar diffusion assay. The pigment extract was effective in inhibiting the growth of pathogenic bacteria and fungi. A comparison of effect of pigment to that of different antibiotics carried out revealed significant information as to whether extracts can be employed as replacements or as an adjunct to chemotherapeutic agents.
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