HEPATO AND NEPHRO TOXICITY IN RAT EXPOSED TO MALATHIONNISHA CHOUDHAR'e, S.C. JOSH! AND REKHA GOYAL
Malathion is widely used pesticide in many countries and has been shown to produce many adverse health effects. In the present study we investigated the toxic effects of malathion on the vital organs viz liver and kidney. Oral administration of malathion at the dose level of 250mg/kg/bwt/day for two and four weeks showed toxic interference with the biochemistry and histology of rat. The biochemical parameters viz aspartate amino transferase, alanine amino transferase, acid phosphatase, bilirubin, urea and creatinine were increased whereas alkaline phosphatase was decreased which clearly showed the hepato and nephrotoxic effects of malathion. Histopathologicaly size of the liver was found to be increased sinusoidal dialation, pycnotic nuclei, cytoplasmic degranulation and various nuclear aberrations were observed. Similarly pathological alterations viz chronic glomerulonephritis. glomeruleroses, odenoma and glomerulus deposits were noticed in the kidney.
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