Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol.13, Issue 2, 2011; Page No.(285-288)

EPIDEMIOLOGICAL SURVEY AND PCR BASED DETECTION OF MUTATION FOR BREAST CANCER IN WEST BENGAL, INDIA

ARPITA CHATTERJEE AND GOPESWAR MUKHERJEE

Abstract

Carcinoma breast was the most prevalent malignant condition among women world-wide. Present investigation on the incidence pattern of breast cancer in rural population of West Bengal revealed that among 3219 malignant cases 39.05% showed breast carcinoma including 99.20% females and 0.79% males. Cancer frequency was moderate during 2004 to 2006, but it increased drastically from 2007 and reached maximum peak (28.00%) in 2009. Carcinoma breast was most prevalent in group O (32.86%) and in particularly middle age group (39.46% in 31-40 years age). A PCR based molecular approach was used to identify the mutation of BRCA2 genes and in very few cases (0.8%) BRCA2 999del5 mutation was detected.

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