Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 07, Issue 2, 2005; Page No.(303-304)

STUDY OF MICRONUCLEI IN EXFOLIATED BUCCAL CELLS FROM SMALL MINE FEMALE WORKERS CHRONICALLY EXPOSED TO SILICA IN SEURI, WEST BENGAL

AJANTA HALDER. MANISHA DE AND MADHUSNATA DE

Abstract

Recently crystalline Silica has been classified as a human carcinogen by Intemational Agency for Research on Cancer (I A RC, 1997). We used the micronucleus (MN) test to determine the genetic damage caused by silica. A plot study was undertaken to evaluate micronudei (MN) frequency in buccal smears of a group of 45 females workers occupationally exposed to silica small Alines and Stone quarries of Seuri, West Bengal (latitude- 23.5499 and longitude- 87.34°E) were the habitual working places of these subjects of study. Average micronucleus frequencies were increased in high-exposure group as compared to normal control. The results indicate that the workers of Sion chronically exposed to silica reveal evidence of genotoxicity in epithelial cell type; higher levels of MN were obsenwd in buccal cell.

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