EFFECTS OF FEEDING A1 AND A2 COW MILK-BASED DIET ON BIOCHEMICAL PARAMETERS IN DIABETIC MICE MODELVIPUL CHAUDHARY, MANISHI MUKESH, VISHAL SHARMA, GAURAV BHAKRI, PAMELA SINGH, SHELESH KUMAR, PREETI SWAMI, PRINCE VIVEK, RANJIT S. KATARIA, SAKET KUMAR NIRANJAN, ASHOK KUMAR MOHANTY AND MONIKA SODHI
Streptozotocin is naturally occurring target specific alkylating agent derived from gram-positive bacterium Streptomyces achromogenes species that triggers an inflammatory mechanism leading to preferential destruction of pancreatic beta cells which is responsible for hyperglycemic states in experimental C-57 BL/6 mice. Cytotoxic effect of Streptozotocin is well established to build type 1 diabetes mellitus (T1DM) study model. We induced diabetes in C57 bl/6 mice by injecting Streptozotocin (dissolved in 0.1 M sodium citrate buffer at pH of 4.4) intraperitoneally at dose of 45mg per kg of body weight for consecutive 5 days. The mice were fed with A1A1 and A2A2 milk and their response was seen at 3 months with respect to their controls. A2A2 diet was not related to the induction of biochemical abnormalities while A1A1 and A1A2 diet have some association to cause some inflammatory reactions.