EVALUATION OF ACUTE ORAL TOXICITY OF A HERBAL UTERINE RESTORATIVE AND CLEANSERSUNIL HAJARE, RANJIT SURESH INGOLE, MAHESHKUMAR VITTHAL INGAWALE, VIVEK BOREKAR, DAVID KUMAR, RAVIKANTH KOTAGIRI AND BHASKAR GANGULYAbstract Maintaining optimum reproductive health of animal is crucial for profitability in livestock enterprises and boosting the economy of farmers. However, the reproductive efficiency of animals is commonly reduced by problems such as puerperal metritis, clinical endometritis, pyometra, subclinical endometritis, early embryonic mortality, repeat breeding, retention of foetal membranes, and post-partum anestrus. ExaparTM Liquid (M/s Ayurvet Limited, India) is a polyherbal uterine cleanser and restorative that helps to achieve and restore better post-partum reproductive efficiency. This study aimed to evaluate the potential of Exapar TM Liquid to induce acute oral toxicity in mice as per OECD 423 guidelines. Nine healthy and adult nulliparous, non-pregnant Swiss albino female mice, weighing 24-28 g, were used for the study. The animals were observed for the manifestation of toxic effects and mortality after the oral administration of the test substance. Toxicity was evaluated on the basis of changes in body weight, signs of toxicity, gross and histological appearances of vital organs, and blood biochemistry. Exapar TM Liquid was found safe for oral use as no toxic effects or mortalities were observed up to the completion of experiment. |