Ecology, Environment and Conservation Paper

ANTICANCER ACTIVITY OF TRISINDOLINA 1 BY INDUCING APOPTOTIC PATHWAY THROUGH PHOSPHORYLATED P53 PROTEIN EXPRESSION

Awik, P.D. Nurhayati, Andina W. Hasanah Mardi Santoso

Abstract

Cancer is an abnormal proliferation that may arise from normal cells due to carcinogenic induction which causes oxidative stress and damaging DNA. Damaged DNA can be repaired in the G1 phase of the cell cycle, or can be eliminated by directing cell to the apoptotic death pathway. Both mechanisms are controlled by tumour suppressor protein p53. Several natural substances are known to have anticancer potential by inducing p53 expression, one of which is Trisindolina 1 that shows cytotoxic effect in several cancer cell lines. In this paper, we review progress on possible anticancer mechanism of Trisindolina 1, mainly by inducing expression of phosphorylated p53 in apoptotic pathway.