EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF DUNALIELLA BARDAWIL (CHLOROPHYCEAE) IN AN EXPERIMENTAL ANIMAL MODELA. JENITTA AND S. JAYASURIYA
The effect of ethanol extract of Dunaliella bardawil was studied for its effect on acute and chronic phase (EEDB) inflammation and analgesic activity in mice. Present study involved analgesic methods such as, acetic acid induced writhing response method, tail clip method, formalin test and anti-inflammatory tests such as zymosan induced arthritis in mice and carrageen an induced paw edema method. The experiments were conducted with 3 different doses (150 mg/kg b.w, 300 mg/kg b.w and 450 mg/kg b.w) of extracts. In acetic acid induced writhing response test, maximum inhibition (59.45%) was obtained at a dose of 450 mg/kg after 3 hrs of drug treatment, whereas paracetamol (standard drug) produced 74.47% inhibition. In tail-clip test, the extract caused a significant (P<0.0001) inhibition of pain, in all the doses. There was a significant dose-dependent inhibition (54.39%) in formalin test. In carageenan induced paw edema, maximum inhibition (60.26%) was obtained at a dose of 450 mg/kg, indomethacin produced 65.78% inhibition and zymosan induced arthritis test showed a significant inhibition (89%). Significant analgesic and anti-inflammatory effects and therapeutic efficacy of EEDB on animal models are comparable with those of standard drugs.
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