Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 14, Issue 3, 2012; Page No.(357-364)

POTENTIATION OF ANTIBIOTIC ACTIVITY BY CITRIC ACID AGAINST MULTIPLE DRUG RESISTANT PSEUDOMONAS AERUGINOSA

PREETI G. DHARMIK, ASHOK V. GOMASHE AND BHARAT J. WADHER

Abstract

Inspite the introduction of a wide variety of antimicrobial agents with anti-pseudomonal activity, life threatening infections caused by Pseudomonas aeruginosa contribute to morbidity and mortality in hospitalized patients. The present study was conducted to determine the antibiotic sensitivity pattern of Pseudomonas aeruginosa obtained from hospitalized patients and potentiation of antibiotic activity by citric acid against multiple drug resistant Pseudomonas aeruginosa. Out of 100 isolates of Pseudomonas aeruginosa, fifty were found to be resistant to one or more antibiotics tested. 0.05% and 0.1% citric acid was found to be effective in increasing the potency of all the antibiotics used in this study.

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