Ecology, Environment and Conservation Paper

GYNURA PROCUMBENS AMELIORATES CADMIUM-INDUCED HEMATOTOXICITY IN MICE

Sugiharto, Anjar Tri Wibowo, Dwi Winarni, Yulia Tri Nurindah Wanti, Anggita Hana Putri Hermanto and Yosephine Sri Wulan Manuhara

Abstract

The objective of this research was to investigate the antioxidant activities methanolic extract of G. procumbens leaves ameliorates cadmium-induced hematotoxicity in mice. Research was conducted using twenty male mice, which were grouped into five treatments: P1 (control), P2 (Cd 100 mg/l), P3 (G. procumbens 100 mg/ L + Cd 100 mg/l), P4 (G. procumbens 200 mg/l + Cd 100 mg/l), P5 (G. procumbens 300 mg/l + Cd 100 mg/l). The results showed Cd exposure significantly increasing concentration of MDA blood serum, ALT and AST levels, but reducing levels of RBC and HGB in mice. Methanolic extract of G. procumbens leaves administration can restore the damaged cell and mainly attributed to its antioxidant properties against Cd intoxication.