THE EFFECT OF SWALLOW’S BIRD NEST EXTRACTS (COLLOCALIA FUCIPHAGA THUNBERG) ON LEVEL OF OXIDATIVE STRESS AND FUNCTION IN LIVERE. WULANDARI, R.A.F. HAPSARI, K.A. AINI, L.S. SAFITRI AND S.F. KRISNADIAbstract Sprague Dawley mice were given swallow's nest extract at a dose of 10, 20 and 40 mg/kg BW per oral previously induced H2O2 on the 31st and 32nd days. In addition, there was also a normal group and a positive control group for vitamin E. After being turned off, the liver was taken and measured the GSH, MDA and AST/ALT activity of the liver tissue. The results showed a MDA level: control (+), normal, 10, 20, 40 mg/KgBW dose of swallow's nest extract: 0,065; 0.050; 0.043; 0.051; 0.070 ng/mg tissues. Then GSH levels: control (+), normal, 10, 20, 40 mg/KgBW dose of swallowâs nest extract: 0.081; 0.077; 0.33; 0.057; 0.077 μg/mg tissues (ANOVA p <0.05), Pearson correlation test results showed a strong positive relationship, whereas the higher the MDA level the higher the GSH level (R = 0,960). AST/ALT ratio: control (+), normal, 10, 20, 40 mg/ KgBW dose of swallow's nest extract: 0.391; 0.377; 0.323; 0.398; 0.42 (ANOVA p >0.05). The histological image of Swallow's Nest extract doses 10 and 40 shows normal cells. Swallow's nest extract can reduce the level of oxidative stress as evidenced by increased GSH and decreased MDA levels, and can also reduce liver damage by reducing AST/ALT activity. Swallow's nest extract does not cause damage to liver cells or tissue. |