THE INFLUENCE OF GUAVA EXTRACT (PSIDIUM GUAJAVA L.) ON HISTOPATHOLOGICAL FEATURE OF WHITE RAT (RATTUS NORVEGICUS) EXPOSED CIGARETTE SMOKEMENTARI RACHMAWATI, RATNA DAMAYANTI AND WURLINAAbstract The purpose of this study was to determine the effect of giving guava extract (Psidium guajava L.) to the histopathological feature of the lung of white rats (Rattus norvegicus) exposed cigarette smoke. This study used 25 male rats with an average body weight of 150-200 gr per head. The negative control group (K-) was given CMC Na 0.5% 2 mL/head without exposure to cigarette smoke. P0 group was given 3 cigarettes and CMC Na 0.5% 2 mL/fish per day. P1, P2 and P3 groups were given 3 cigarettes as much exposure to cigarettes and 3.78 mg / 200g BW, 7.58 mg / 200g BW, 11.34 / 200g BW, respectively. Provision of cigarette smoke and guava extracts carried out for 45 days. The results showed that the administration of guava extract (Psidium guajava L.) can repair congestion damage and thickening of white rat alveoli at the highest dose of 11.34 mg/200g BW. Based on the results of the Kruskal Wallis statistical analysis p = 0.000 which shows there are significant differences, further tests using Mann Whitney show there are differences in each group. The conclusion of this study is the administration of guava extract can improve congestion damage and thickening of white rat septa alveoli which are exposed to cigarette smoke. |