THE COMPARATIVE TOXICITY EFFECTS OF LEAD AND CADMIUM EXPOSURE ON HEMATOLOGICAL PARAMETERS AND ORGANS OF MICESugiharto, Yosephine Sri Wulan Manuhara, Anjar Tri Wibowo, Dwi Winarni, Ufairanisa Islamatasya, and Us Watun Nurul Khasanah
The hematopoietic system is very susceptible to lead (Pb) and cadmium (Cd) poisoning, because the metal is bound mostly to erythrocytes and blood plasma. It can cause fragility and damage to blood cells and accumulate in tissues. It leads to cause damage to tissue or organs. The aim of this research was to investigate the comparison toxicity effects of lead and cadmium exposure on hematological parameters (red blood cell count/RBC, hemoglobin concentration/HGB, hematocrit/HCT, mean corpuscular volume/MCV, mean corpuscular hemoglobin concentration/MCHC, mean corpuscular hemoglobin/MCH, platelet count/PLT, differential count percentage of lymphocytes, monocytes, and granulocytes), and weight of organs (liver, spleen, and kidney) in mice. Research was conducted using twenty five male mice, which were grouped into five treatments: P1 = control, P2 = Pb 50 mg/L, P3 = Pb 100 mg/L, P4 = Cd 50 mg/L, and P5 = Cd 100 mg/L. The results showed that to compare the control group, Lead and cadmium exposure are significantly shifted to decrease in RBC, HGB, HCT, percentage of granulocytes, body weight and liver weight; on the contrary increase PLT and percentage of lymphocytes. Lead exposure can increase the value of MCHC and MCH, whereas cadmium exposure actually reduces the value of MCHC and MCH in comparison to the control group.