FORMULATION AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF POLYHERB GELSaba Shaikh, Rimsha Sarguru, Munazza Shaikh and Hawai OwaisAbstract Ethanopharmacology and natural products provides a significant hope in drug development. Indeed today many pharmacological classes of drugs available in the market are derived from natural products as herbal drugs have less side effect and safe when compared with the synthetic drugs. The present study was undertaken to investigate the antimicrobial activity of polyherb gel. In this study we have formulated 1% polyherb gel which consists of aqueous extract of Hibiscus sabdariffa and aqueous extract of Amarathus cruentus. The base was prepared by using carbapol 940, propylene glycol-400, sodium CMC, sodium benzoate and required amount of distilled water in a quantity sufficient to prepare 10 g. The prepared formulations were evaluated for their antimicrobial activity by disk diffusion technique against S. aureus and E. coli which are indicative types of gram positive and gram negative organisms. The formulations were also assessed for appearance and homogeneity, pH, viscosity and rheological studies, spreadability. The results obtained in the present study indicate that the polyherb gel shows antimicrobial activity. As per the results obtained, it could conclude that this polyherb gel possesses antimicrobial activity. |