Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

EVALUATION OF ACUTE ORAL TOXICITY OF A POLYHERBAL POULTRY COCCIDIOSTAT

SUNIL HAJARE, MADHURI HEDAU, MAHESHKUMAR INGAWALE, SUNIDHI, RAVIKANTH KOTAGIRI AND BHASKAR GANGULY

Abstract

The current study was designed to evaluate the acute oral toxicity potential of Coccihar™ (M/ s Ayurvet Limited, Baddi, India) according to OECD 423 guidelines. Coccidiosis is recognized as a major parasitic disease of poultry resulting in loss of productivity. Coccihar™ is a herbal Coccidiostat recommended for the prevention of coccidiosis, for improvement of intestinal health, growth performance and weight gain in poultry. Nine female Swiss albino mice were used for the study. Each animal served as its own control. Following the oral administration of the test substance, the animals were observed for manifestation of toxic effects and deaths. No toxic effects or mortalities were observed. The estimation of biochemical parameters (AST, ALT, ALP and creatinine) and histopathological studies also did not reveal any significant findings. Hence, Coccihar™ was found to be safe for oral use.