EXPRESSION PROFILE OF IL-1β IN PESTE DES PETITS RUMINANTS (PPR) VACCINATED GOATSD. K. SHARMA, B. JOSEPH, R. SINGATHIA, R. DADICH, A. GAURAV, S.K. SHARMA, R. K. NAGDA, V. KUMAR AND K. SOKHAL
Peste des petits ruminant virus (PPRV) is associated with peracute and acute multi-systemic disease of sheep and goat commonly known as goat plague. It is characterized by profound immune suppression and leucopenia. In healthy animals, innate viral recognition pathways trigger release of molecules with direct anti-viral activities and pro-inflammatory mediators which recruit immune cells to support viral clearance. Interleukin-1Î² (IL-1Î²) has critical roles in the establishment of inflammation. In this study, the gene expression of IL-1Î² was investigated by quantitative real time PCR (qRT-PCR) in peripheral blood mononuclear cells (PBMCs) of PPRV vaccinated goats. The expression level of IL-1Î² remained elevated from 14 days post vaccination (dpv) and relative fold change in mRNA expression was increased up to 150 folds.