ASSOCIATION BETWEEN SERUM CARTILAGE OLIGOMERIC MATRIX PROTEIN LEVEL AND KNEE OSTEOARTHRITIS SEVERITY IN ELDERLY AT PUBLIC HEALTH CARE CLINICS UIN SYARIF HIDAYATULLAH JAKARTA IN 2017ACHMAD ZAKI, FIKA EKAYANTI, MERY NITALIA AND ASIAH MUTHIAH
Osteoarthritis is a chronic degenerative disease caused by degeneration of cartilage in the joints that increased friction between bones. Data from Riskesdas survey released by MoH RI 2013 reveals the prevalence of osteoarthritis (OA) at 24.7% while an independent study by Sonjaya (2016) shows that knee OA prevalence in Indonesia was about 45.58% between the age of 56-65. Serum cartilage oligomeric matrix protein (sCOMP) was proposed as a biomarker for OA severity. To identify the association between serum COMP level of knee OA patient and OA severity assessed by Kellgren-Lawrence radiological classification. This study used a cross-sectional design at KPKM Reni Jaya UIN Syarif Hidayatullah Jakarta in February- Mei 2017 with a consecutive sampling. sCOMP level obtained from peripheral blood serum while radiographic imaging of the knee used for Kellgren-Lawrence evaluation. Respondents were given informed consent before enrolled in this study. Data were checked for variance and normality using boxplot, histogram, kurtosis, and skewness ratio before undergoing statistical analysis using Real Statsadd-in for Microsoft Excell 2016. Serum COMP level shows a significant association with age (p=0.001) and severity of OA (p=0.01). Analysis within the age subgroup of elderly shows that severity of OA was dependent on age with moderate effect size (0.24). A significant difference of serum COMP between mild and moderate severity of OA also present in the female, normal weight and advanced elderly (70-79) subgroups (p<0.05). Serum COMP level of OA patient significantly associated with a mild and moderate case of OA according to Kellgren-Lawrence classification.