Pollution Research Paper

DIMETHOATE TOXICITY: A HAEMATOLOGICAL AND BIOCHEMICAL APPROACH IN SWISS ALBINO MICE AND REMEDIAL EFFECTS OF LEAF EXTRACT OF ZIZYPHUS

NUMMULARIA SABIHA KHAN AND TASLIM AKHTER

Abstract

Pesticides are used for destroying, repelling or mitigating any pest not to affect human health. These are grouped under the basis of target organisms, eg - Algicide for Algae, Avicide for Birds, Bacteriocide for Bacteria, Fungicide for Fungi, Insecticide for Insects, Nematicide for Nematodes, Rodenticide for Rodents, Virucide for Viruse etc. Dimethoate is the organophosphate is used extensively in horticulture. The purpose of the research work is to deal with the effect of leaf extract of Zizyphus nummularia on the haematological and Biochemical parameters of dimethoate treated albino mice. animals were divided into two group of two different ages (70 days and 105 days) and each group again divided into three group of albino mice.G1A- (Control group of 70 days aged mice ), G2A-[Dimethoate (30 mg/kg.bw) day–1] 70 days aged mice, G3A [Dimethoate (30 mg/ kg.bw) day-1 and 60 min after Zizyphus nummularia leaf extract (250 mg/kg.bw day–1)] 70 days aged mice,and G1B- (Control group of 105 days aged mice), G2B-[Dimethoate (30 mg/kg.bw) day–1] 105 days aged mice, G3B [Dimethoate (30 mg/kg.bw) day-1 and 60 min after Zizyphus nummularia leaf extract (250 mg/kg.bw day–1)] 105 days aged mice. Dimethoate administration significantly altered the Haemoglobin(Hb), Erythrocyte Sedimentation Rate(ESR), Red Blood Cells (RBC conut), Lactate dehydrogenase (LDH) and Adenosine Triphosphatase (ATPase) and co- administration of leaf extract of Zizyphus nummularia showed the protective effects on these parameters.