THE EFFECTS OF LEAD ACETATE EXPOSURE ON BLOOD COMPONENT AND KIDNEY: THE MECHANISM OF OXIDATIVE STRESSSugiharto, Win Darmanto, Sri Puji Astuti W., Kevita Putri, Nur Khoirunnisa, Dea B. Mulyawan, and Arin N. Shanti
Lead (Pb) may induce oxidative stress and it can increase the production of free radicals. Lead exposure increased of malondialdehyde (MDA) and reduced super oxide dismutase (SOD) level in mice blood serumand increased lead levels in the liver. It can induce several responses in physiological and bio chemical functions of the body, especially to biochemical of blood components and kidney. The objective of thisresearch was to evaluate the effect of lead acetate exposure on levels of aspartate amino transferase (AST)and alanine aminotransferase (ALT), hemoglobin (Hb) concentration, the number of red blood cells (RBC),also glomeruli kidney in mice. Research was conducted using eighteen male mice, which were grouped into three treatments: P1 (control), P2 (Pb 75 mg/kg BW), P3 (Pb 150 mg/kg BW). The results showed thatto compare the control group, lead exposure significantly shift to enzyme ALT levels, Hb concentration,RBC numbers, percentages of glomeruli (especially in normal, swollen, and contracted glomeruli), Bowmanâs capsule diameters, and glomeruli â Bowmanâs ratio. On the contrary, the AST levels and glomeruli diameter are insignificantly compared to the control group.