Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 22, Issue 1, 2020; Page No.(194-199)

EVALUATION OF BIOACTIVE POTENTIAL OF 1-BENZYL INDOLE-3- CARBOXY ALDEHYDINE THIOSEMI CARBAZONE SCHIFF BASE LIGAND USING PATHOGENS

PIRAKATHISWARAN G., DHASARATHAN, P., SELVAN. A. AND M. THENMOZHI

Abstract

In the present study aimed to investigate antimicrobial potential of 1-Benzyl Indole-3-carboxy aldehydine thiosemi carbazone Schiff base ligand against human pathogens. A pilot screening of the extracts were carried out by impregnating a 6 mm sterile Whatmann number 1 filter paper discs. The disc was loaded with the 1-Benzyl Indole-3-carboxy aldehydine thiosemi carbazone Schiff base ligand to give a final load of 100,150 and 200 mg /disc. The discs were placed on the Petri plate previously seeded with the respective pathogenic strains. The inhibition – zone width was measured and calculated. The whole chemical showed less activity against P. aeruginosa (6.7 ± 0.3 mm). The purified 1-Benzyl Indole-3-carboxy aldehydine thiosemi carbazone Schiff base ligand (200 mg /disc) showed a high inhibitory action against A. hydrophila (8.1 ± 0.3 mm) and minimum effect on S. aureus (5.6±0.2mm). The crude 1-Benzyl Indole-3-carboxy aldehydine thiosemi carbazone Schiff base ligand a maximum activity against P. aeruginosa (7.2 ±0.1 mm) and minimum activity against C. tetani (3.6 ± 0.1). Of the three samples tested, antibacterial activity was more pronounced in purified 1-Benzyl Indole-3-carboxy aldehydine thiosemi carbazone Schiff base ligand. Antifungal activity of the three samples was evaluated, it was very interesting to observe that all the above three components registered a good antifungal activity. The purified 1-Benzyl Indole-3-carboxy aldehydine thiosemi carbazone Schiff base ligand at a dose level of 200 mg/disc showed the highest inhibitory activity. A dose dependent variations of 1-Benzyl Indole-3-carboxy aldehydine thiosemi carbazone Schiff base ligand were observed in the antimicrobial activity. From the results purified 1-Benzyl Indole-3-carboxy aldehydine thiosemi carbazone Schiff base ligand have bioactive potential antimicrobial compounds.

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