THE STABILITY EVALUATION OF LOSARTAN POTASIUM TOWARDS THE INFLUENCE OF PH AND LIGHT USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHYNELLY SURYANI, YARDI SAIBI, SUPANDI AND TIARA APRILIAAbstract Considering the patient condition, some solid dosage form need to be suspended in water before administration to patient either in single or togather with other drugs. This preparation may change the the condition of the solution and affect to the drugs in it. The objective of this research was to evaluate the influence of pH and light towards losartan potassium that suspends in water. The percentage of losartan potassium suspension concentration was measured using High-Performance Liquid Chromatography based on the method of United Stated Pharmacopeia. Losartan potassium suspension was tested in several conditions, i.e suspended in pH 4 and pH 7 with protected and unprotected light, the testing was done by sampling at a time series, i.e 0, 15, 30, 45, and 60 minutes. The results showed that the suspension of losartan potassium could be stored for 45 minutes with the concentration of 98.63% for pH 4 with unprotected light condition; 98.89% for pH 7 with unprotected light condition; 98.55% for pH 4 with protected light conditions; and 99.06% for pH 7 with protected light condition. The result of this study showed that after 45 minutes, losartan potassium suspension did not meet the requirement in the monograph which was 101.0 to 98.5%. This research showed that the effect of pH and light on losartan potassium suspension did not give a significant difference. |