Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 21, Issue 4, 2019; Page No.(892-895)

DIAGNOSTIC VALUE COMBINATION COPEPTIN ULTRASENSITIVE WITH HIGH SENSITIVE CARDIAC TROPONIN T (HS-CTNT) IN NON ST SEGMENT ELEVATION SUSPECT ACUTE CORONARY SYNDROME

MUNIROH, INA S TIMAN, DANIEL TOBING AND ASTUTI GIANTINI

Abstract

Early and proper acute coronary syndrome diagnosis needed for rapid and proper the theurapeutic. The purpose of this study was to determine the diagnostic value combination copeptin ultrasensitive and hs-cTnT in suspected of acute coronary syndromes patients with ECG images showing non ST elevation. Between October until November 2015, we included 91 consecutive patients suspect acute coronary syndrome patients from emergency department (ED). We measured copeptin ultrasensitive and hs-cTnT on admission and hs-cTnT after 3 hours later. Mean value copeptin-us for NSTEMI was 151.80 ± 130.03 pmol/L, median copeptin-us for unstable angina was 7.12 [1.145 – 62.23 ] pmol/L and mean copeptinus for non ACS was 7.36 ± 4.17 pmol/L. Area under curve (AUC) combination copeptin-us with hs-cTnT was 0.941 (0.82 – 1.00). We obtained diagnostic value combination copeptin-us e” 13.97 pmol / L with hs-cTnT e” 14 pg / mL on admission to distinguish NSTEMI with unstable angina/no ACS for sensitivity 100%, specificity 90.78%, positive predictive value 68.18%, and negative predictive value 100%. Diagnostic value combination copeptin-us with hs-cTnT on admission better than hs-cTnT on admission only and it can use to rule out acute myocardinfark.

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