Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 21, Issue 4, 2019; Page No.(873-875)

KAYU ULAR (STRYCHNOS LIGUSTRINA) DRY EXTRACT PREVENTS FROM HYPERGLYCEMIA IN CHRONIC DIABETES INDUCED BY STREPTOZOTOCIN

HARI HENDARTO, FLORI R. SARI, FEMMY NURUL AKBAR, CHRIS ADHIYANTO3, RIZKIANI JULESHODIA WULANDARI, AGUNG SAPUTRA, LILIS SITI NURSAADAH AND RAHAYU SRI WAHYUNI

Abstract

Kayu Ular or Strychnos ligustrina have been traditionally used in Indonesia as an anti diabetic agent. The objective of this study was to determine anti-hyperglycemic agent activities of Kayu Ular extracts which are traditionally used in the treatment of diabetes in Indonesia. Diabetic rat were given Kayu Ulardry extract orally once a day with the dose of 8,5 mg/kg BW for 84 days. Blood glucose level were evaluated on the day 1, 28, 56 and 84. Daily decoction of Kayu Ulardry extract significantly reduced blood glucose level in streptozotocin (STZ)-induced diabetic rats, suggesting the further potential of Kayu Ularas diabetic drug.

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