Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 21, Issue 4, 2019; Page No.(840-845)

IN VITRO CYTOTOXIC STUDY FOR COMPARISON BETWEEN EFFECT OF GOLD AND SILVER NANOPARTICLES AGAINST CANCER CELLS LINES

SUMAIAH I. HUSSEIN, NAWFAL N.R. AL-RAWI, SHAIMAA S. MUTLAK, MAYSSA K. AL-MALKY, HEBA F. HASSAN AND NAHI Y. YASEEN

Abstract

Cancer is a large problem in the world, so the traditional treatment is not efficient in eradication the body from cancer cells. Recently, Nanotechnology in medicine involves applications of nanoparticles currently under development, especially the nobel elements such as gold and silver. In the present study, we investigated the effects of AgNPs and AuNPs on cytotoxicity of two cell lines Hepatocyte cancer cell line for mice (HC) and breast cancer cell line for human (MCF-7). Five concentration (0.625-10) μg were used from each particle and for each cell line for comparison between the effect of AgNPs and AuNPs. The study reveals that Au NPs and Ag NPs have effect on this cell line but the AuNPs have more effect than the Ag NPs, so the effect is related to concentration and cell type-dependent manner.

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