Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper

Vol 21, Nov. Suppl. Issue, 2019; Page No.(38-43)

HYPOXIA INDUCIBLE FACTOR 1 ALPHA (HIF-1 ALPHA) AS MARKER OF NEURONAL PLASTICITY AFTER ISCHEMIC STROKE

YETTY RAMLI, RINEKE T. ARANDITA AND M. SADIKIN

Abstract

HIF-1 alpha is the main transcription factor protein for adaptive brain response in hypoxia. Studies regarding the role of HIF-1 alpha in the post-stroke recovery have been largely conducted. HIF-1 alpha is found to have a role with Neural Stem/Progenitor Cell (NSPC) in the brain of adults in hypoxic state of stroke. The Hypothesis of HIF-1 alpha establishes the activation of hypoxic-adaptive genes that contributes to the possibility of the recovery of brain functions following ischemic stroke is still being researched. Male Wistar rats were classified into 5 groups : normal group (n=5), 1 day MCA Occlusion (MCAO) Group (n=5), 3-day MCAOGroup (n=5), 5-day MCAO Group (n=5), and 7-day MCAO group n=5). HIF-1 alpha Expressions in each group were conducted based on the occlusion days, with functional evaluation of Rotarod test. HIF-1 alpha sexpressions were significantly increased in 1-day MCAO, 3-day MCAO, and 5- day MCAO groups compared to control group (p<0.05). However, the Rotarod test was only significantly worsened in the 1-dayMCAO group compared to baseline (p<0.05). Increased expression of HIF-1 alpha in acute stroke group had negative relationship with the functional status of the stroke rats model

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